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5 March 2021 Enhancing liver on a chip Complex In Vitro Model studies using label-free optical imaging
Aneesh Alex, BanuPriya Sridharan, Edita Aksamitiene, Chi Zhang, Jindou Shi, Prabuddha Mukherjee, Mantas Zurauskas, Darold R. Spillman Jr., Marina Marjanovic, Jason Ekert, Steve Hood, Stephen A. Boppart
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Proceedings Volume 11624, Visualizing and Quantifying Drug Distribution in Tissue V; 116240G (2021) https://doi.org/10.1117/12.2578531
Event: SPIE BiOS, 2021, Online Only
Abstract
Recent advances in tissue engineering and microfabrication have led to development of novel Complex In Vitro models (CIVMs) that more closely mimic pathophysiological functions of human tissues and organs. CIVMs can provide deeper insights into the mechanisms of human disease and pharmacological properties of new drug candidates during early stages of development. In this study, a multimodal optical imaging platform was used for characterizing the structural and functional features of a liver-on-a-chip model (CN Bio Innovations, UK).
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Aneesh Alex, BanuPriya Sridharan, Edita Aksamitiene, Chi Zhang, Jindou Shi, Prabuddha Mukherjee, Mantas Zurauskas, Darold R. Spillman Jr., Marina Marjanovic, Jason Ekert, Steve Hood, and Stephen A. Boppart "Enhancing liver on a chip Complex In Vitro Model studies using label-free optical imaging", Proc. SPIE 11624, Visualizing and Quantifying Drug Distribution in Tissue V, 116240G (5 March 2021); https://doi.org/10.1117/12.2578531
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KEYWORDS
Optical imaging
Animal model studies
In vitro testing
Multiphoton microscopy
3D modeling
Microscopy
Multiphoton fluorescence microscopy
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