ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study

Shudong Jiang; Jonathan T. Elliott; Jin Xing; Xu Cao; Xiaohan Yu; Xinyue Han; Rebecca E. Dabrowski; Melanie L. Christian; Eric R. Henderson; Brian W. Pogue; I. Leah Gitajn

doi:10.1117/12.2578976

5 March 2021 ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study

Shudong Jiang, Jonathan T. Elliott, Jin Xing, Xu Cao, Xiaohan Yu, Xinyue Han, Rebecca E. Dabrowski, Melanie L. Christian, Eric R. Henderson, Brian W. Pogue, I. Leah Gitajn

Author Affiliations +

Proceedings Volume 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII; 116250W (2021) https://doi.org/10.1117/12.2578976
Event: SPIE BiOS, 2021, Online Only

Abstract

Forty two patients with high energy open fractures were involved into the study to investigate whether an indocyanine green (ICG)-based dynamic contrast-enhanced fluorescence imaging (DCE-FI) can be used to objectively assess bone perfusion and guide surgical debridement. For each patient, fluorescence images were recorded after 0.1 mg/kg of ICG was administered intravenously. By utilizing a bone-specific kinetic model to the video sequences, the perfusion-related metrics were calculated. The results of this study shown that the quantitative ICG-based DEC-FI can accurately assess the human bone perfusion during the orthopedic surgery.

Citation Download Citation

Shudong Jiang, Jonathan T. Elliott, Jin Xing, Xu Cao, Xiaohan Yu, Xinyue Han, Rebecca E. Dabrowski, Melanie L. Christian, Eric R. Henderson, Brian W. Pogue, and I. Leah Gitajn "ICG-based dynamic contrast-enhanced fluorescence imaging guided open orthopaedic surgery: pilot patient study", Proc. SPIE 11625, Molecular-Guided Surgery: Molecules, Devices, and Applications VII, 116250W (5 March 2021); https://doi.org/10.1117/12.2578976

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