Methylene blue photodynamic therapy to sterilize deep tissue abscess cavities: a phase 1 trial in progress and simulation study

Timothy M. Baran; Lam Nguyen; Thomas H. Foster; Ashwani K. Sharma

doi:10.1117/12.2575949

5 March 2021 Methylene blue photodynamic therapy to sterilize deep tissue abscess cavities: a phase 1 trial in progress and simulation study

Timothy M. Baran, Lam Nguyen, Thomas H. Foster, Ashwani K. Sharma

Author Affiliations +

Proceedings Volume 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021; 116260N (2021) https://doi.org/10.1117/12.2575949
Event: SPIE BiOS, 2021, Online Only

Abstract

Despite advances in image-guided percutaneous drainage, deep tissue abscesses remain a serious cause of morbidity, mortality, and hospital stay. We initiated a Phase 1 clinical trial exploring safety and feasibility of methylene blue (MB) photodynamic therapy during drainage. Five subjects have been treated, with no study-related adverse events and high technical success. Monte Carlo simulations were used to examine effects of optical properties on delivered light dose. We found that light dose is highly dependent upon MB uptake and Intralipid concentration. These results motivated construction of an optical spectroscopy system for determination of abscess wall optical properties in vivo.

Conference Presentation

Citation Download Citation

Timothy M. Baran, Lam Nguyen, Thomas H. Foster, and Ashwani K. Sharma "Methylene blue photodynamic therapy to sterilize deep tissue abscess cavities: a phase 1 trial in progress and simulation study", Proc. SPIE 11626, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2021, 116260N (5 March 2021); https://doi.org/10.1117/12.2575949

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