Longitudinal OCT tracking of antibiotic treatment response on experimentally induced otitis media

Jungeun Won; Wenzhou Hong; Pawjai Khampang; Darold R. Spillman Jr.; Samuels Marshall; Ke Yan; Ryan G. Porter; Michael A. Novak; Joseph E. Kerschner; Stephen A. Boppart

doi:10.1117/12.2577289

5 March 2021 Longitudinal OCT tracking of antibiotic treatment response on experimentally induced otitis media

Jungeun Won, Wenzhou Hong, Pawjai Khampang, Darold R. Spillman Jr., Samuels Marshall, Ke Yan, Ryan G. Porter, Michael A. Novak, Joseph E. Kerschner, Stephen A. Boppart

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Proceedings Volume 11627, Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology; 1162709 (2021) https://doi.org/10.1117/12.2577289
Event: SPIE BiOS, 2021, Online Only

Abstract

To non-invasively assess the impact of antibiotic therapy on otitis media (OM), a handheld OCT system was developed to longitudinally monitor in vivo middle ear conditions of OM-induced chinchilla models. The formation of middle ear effusions (MEEs) and biofilm were examined over the course of the infection. Furthermore, the effect of antibiotics on the biofilm as well as the amount and type of MEEs was investigated with low-dose and high-dose antibiotics (ceftriaxone). Quantitative parameters, such as TM thickness and effusion and biofilm scattering/texture, were correlated with histology and fluorescence in situ hybridization (FISH) at the end time point.

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Jungeun Won, Wenzhou Hong, Pawjai Khampang, Darold R. Spillman Jr., Samuels Marshall, Ke Yan, Ryan G. Porter, Michael A. Novak, Joseph E. Kerschner, and Stephen A. Boppart "Longitudinal OCT tracking of antibiotic treatment response on experimentally induced otitis media", Proc. SPIE 11627, Photonic Therapeutics and Diagnostics in Dentistry, Head and Neck Surgery, and Otolaryngology, 1162709 (5 March 2021); https://doi.org/10.1117/12.2577289

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KEYWORDS

Optical coherence tomography

Animal model studies

Ear

Bacteria

Diagnostics

Human subjects

In vivo imaging

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