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5 March 2021 Correlation of non-invasive diffuse optical measurements of cerebral hemodynamics and cerebral microdialysis during extracorporeal membrane oxygenation
Tiffany S. Ko, Emilie J. Benson, Julia C. Slovis, Lindsay E. Volk, Constantine D. Mavroudis, Ryan W. Morgan, Jake Breimann, Jharna Jahnavi, Jonathan P. Starr, William P. Landis, Thomas Hallowell, Nile Delso, Kristen N. Andersen, Jonah A. Padawer-Curry, Anna L. Roberts, Yuxi Lin, Kathryn Graham, Richard W. Melchior, Arjun G. Yodh, Robert A. Berg, Wesley B. Baker, Todd J. Kilbaugh, Daniel J. Licht
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Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 1162918 (2021) https://doi.org/10.1117/12.2577803
Event: SPIE BiOS, 2021, Online Only
Abstract
We examine the correlation of non-invasive, frequency-domain diffuse optical spectroscopy (FD-DOS) and diffuse correlation spectroscopy (DCS) measurements of cerebral tissue oxygen extraction fraction (OEF) and relative cerebral blood flow (rCBF) with invasive cerebral microdialysis measurement of the cerebral lactate-pyruvate ratio (LPR), a biomarker of metabolic stress, during extracorporeal membrane oxygenation (ECMO) in a pediatric swine model of ECMO assisted cardiopulmonary resuscitation (n=15). During 22-24 hours of ECMO, non-invasive FD-DOS/DCS neuromonitoring of OEF and rCBF demonstrated significant correlations with cerebral LPR. Non-invasive detection of critical neurometabolic stress at the bedside may facilitate brain-targeted ECMO management after cardiac arrest.
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Tiffany S. Ko, Emilie J. Benson, Julia C. Slovis, Lindsay E. Volk, Constantine D. Mavroudis, Ryan W. Morgan, Jake Breimann, Jharna Jahnavi, Jonathan P. Starr, William P. Landis, Thomas Hallowell, Nile Delso, Kristen N. Andersen, Jonah A. Padawer-Curry, Anna L. Roberts, Yuxi Lin, Kathryn Graham, Richard W. Melchior, Arjun G. Yodh, Robert A. Berg, Wesley B. Baker, Todd J. Kilbaugh, and Daniel J. Licht "Correlation of non-invasive diffuse optical measurements of cerebral hemodynamics and cerebral microdialysis during extracorporeal membrane oxygenation", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 1162918 (5 March 2021); https://doi.org/10.1117/12.2577803
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KEYWORDS
Hemodynamics
Optical testing
Cerebral blood flow
Diffuse optical spectroscopy
Injuries
Oxygen
Spectroscopy
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