Optical property revealing vascular network and pathological lesion in human brain tissues with as-PSOCT

Hui Wang; Robert J. Jones; Divya Varadarajan; Caroline Magnain; Anastasia Yendiki; Jonathan R. Polimeni; Bruce Fischl

doi:10.1117/12.2579506

5 March 2021 Optical property revealing vascular network and pathological lesion in human brain tissues with as-PSOCT

Hui Wang, Robert J. Jones, Divya Varadarajan, Caroline Magnain, Anastasia Yendiki, Jonathan R. Polimeni, Bruce Fischl

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291F (2021) https://doi.org/10.1117/12.2579506
Event: SPIE BiOS, 2021, Online Only

Abstract

The vascular network in the human brain is universally involved in physiology and neural activity and the alteration is commonly associated with neurological disorders such as traumatic brain injury, stroke, multiple sclerosis, and Alzheimer’s disease. However, small arterioles, venules, and the capillary networks are beyond the resolution of in vivo MRI and optical microscopy only reveals the vasculature of cortex in small animals. We reported a vascular network reconstruction with an automatic serial sectioning polarization sensitive optical coherence tomography at 3.5 micrometer resolution in ex vivo human brain tissue. Pathological patterns surrounding the vessel walls were revealed as well.

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Hui Wang, Robert J. Jones, Divya Varadarajan, Caroline Magnain, Anastasia Yendiki, Jonathan R. Polimeni, and Bruce Fischl "Optical property revealing vascular network and pathological lesion in human brain tissues with as-PSOCT", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291F (5 March 2021); https://doi.org/10.1117/12.2579506

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KEYWORDS

Brain

Tissues

Optical coherence tomography

Optical properties

Capillaries

Brain mapping

Image resolution

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