Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice

Jianbo Tang; Xiaojun Cheng; Kivilcim Kilic; Anna Devor; Jonghwan Lee; David A. Boas

doi:10.1117/12.2578773

5 March 2021 Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice

Jianbo Tang, Xiaojun Cheng, Kivilcim Kilic, Anna Devor, Jonghwan Lee, David A. Boas

Author Affiliations +

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116291L (2021) https://doi.org/10.1117/12.2578773
Event: SPIE BiOS, 2021, Online Only

Abstract

We report optical coherence tomography (OCT) imaging of localized fast optical signals (FOS) arising from whisker stimulation in awake mice. The activated voxels were identified by fitting the OCT intensity signal time course with a response function over a time scale of a few hundred milliseconds after the whisker stimulation. The significantly activated voxels were shown to be localized to the expected brain region for whisker stimulation. The ability to detect functional stimulation-evoked, depth resolved FOS with intrinsic contrast from the cortex provides a new tool for neural activity studies.

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Citation Download Citation

Jianbo Tang, Xiaojun Cheng, Kivilcim Kilic, Anna Devor, Jonghwan Lee, and David A. Boas "Imaging localized fast optical signals of neural activation with optical coherence tomography in awake mice", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116291L (5 March 2021); https://doi.org/10.1117/12.2578773

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