Multi-exposure interferometric diffusing wave spectroscopy (MiDWS)

Wenjun Zhou; Mingjun Zhao; Oybek Kholiqov; Vivek J. Srinivasan

doi:10.1117/12.2578957

5 March 2021 Multi-exposure interferometric diffusing wave spectroscopy (MiDWS)

Wenjun Zhou, Mingjun Zhao, Oybek Kholiqov, Vivek J. Srinivasan

Proceedings Volume 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics; 116292G (2021) https://doi.org/10.1117/12.2578957
Event: SPIE BiOS, 2021, Online Only

Abstract

Maintenance of cerebral blood flow (CBF) is required for normal brain function. Yet, measuring CBF in adult humans requires high-end medical instrumentation. Here, leveraging two-dimensional (2D) complementary metal-oxide-semiconductor (CMOS) technology, we present and validate an optical approach, called multi-exposure interferometric Diffusing Wave Spectroscopy (MiDWS), to monitor blood flow index (BFI), a proxy for CBF, via the adult human forehead. MiDWS employs interferometry to detect low light levels, and probes the optical field autocorrelation by varying the sensor exposure time. This approach may enable human brain optical BFI monitoring with 2D CMOS sensors, with associated economies of scale.

Conference Presentation

Citation Download Citation

Wenjun Zhou, Mingjun Zhao, Oybek Kholiqov, and Vivek J. Srinivasan "Multi-exposure interferometric diffusing wave spectroscopy (MiDWS)", Proc. SPIE 11629, Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics, 116292G (5 March 2021); https://doi.org/10.1117/12.2578957

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