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In this work we present a retinal imaging system that incorporates full-field (FF) swept-source (SS) optical coherence tomography (OCT) with hardware adaptive optics (AO) correction operating in real time. We demonstrate that this configuration permits resolution of foveal cones, with volume rates adequate to measure light-evoked changes in photoreceptors. With the OCT reference arm blocked, the system is a high speed (kHz) AO flood illumination (FI) camera, supporting future studies of optoretinographic responses through common path interference. The characterization and demonstration of the system performance with in vivo human photoreceptor mosaic are presented.
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Denise Valente, Kari V. Vienola, John S. Werner, Robert J. Zawadzki, Ravi S. Jonnal, "A retinal full-field swept-source optical coherence tomography and flood imaging system with hardware adaptive optics," Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 116300F (5 March 2021); https://doi.org/10.1117/12.2583905