Multimodality optical coherence tomography based tethered capsule endomicroscopy for upper gastrointestinal tract imaging

Andreas Wartak; Yuxiao Wei; Ara Bablouzian; Paola Leon Alarcon; Keval Bollavaram; Osman Ahsen; Edward Farewell; Schuyler VanTol; Alfred Kelada; Abigail Gregg; Aaron Baillargeon; Patricia Grahmann; Joseph Gardecki; Guillermo J. Tearney

doi:10.1117/12.2582536

5 March 2021 Multimodality optical coherence tomography based tethered capsule endomicroscopy for upper gastrointestinal tract imaging

Andreas Wartak, Yuxiao Wei, Ara Bablouzian, Paola Leon Alarcon, Keval Bollavaram, Osman Ahsen, Edward Farewell, Schuyler VanTol, Alfred Kelada, Abigail Gregg, Aaron Baillargeon, Patricia Grahmann, Joseph Gardecki, Guillermo J. Tearney

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Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 116300P (2021) https://doi.org/10.1117/12.2582536
Event: SPIE BiOS, 2021, Online Only

Abstract

We introduce two multimodal extensions of our optical coherence tomography (OCT) based tethered capsule endomicroscopy (TCE) platform, tailored towards an enhanced clinical applicability for upper gastrointestinal tract imaging. The first extension presented – white light (RGB)-OCT-based TCE – provides both, true-color visualization of the tissue surface and depth-resolved sub-surface OCT imaging, co-registered in time and space. The second extension presented – fluorescence (FL)-OCT-based TCE – enables the addition of tissue specific molecular contrast. We present compact, modular, easily portable, plug-and-play system designs for both extensions, as well as imaging results in swine esophagus, in vivo.

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Andreas Wartak, Yuxiao Wei, Ara Bablouzian, Paola Leon Alarcon, Keval Bollavaram, Osman Ahsen, Edward Farewell, Schuyler VanTol, Alfred Kelada, Abigail Gregg, Aaron Baillargeon, Patricia Grahmann, Joseph Gardecki, and Guillermo J. Tearney "Multimodality optical coherence tomography based tethered capsule endomicroscopy for upper gastrointestinal tract imaging", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 116300P (5 March 2021); https://doi.org/10.1117/12.2582536

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