Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography

P. Mukherjee; A. Miyazawa; L. T. W. Shen; S. Fukuda; T. Yamashita; Y. Oka; I. G. Abd El-Sadek; S. Makita; S. Matsusaka; T. Oshika; H. Kano; Y. Yasuno

doi:10.1117/12.2577994

9 March 2021 Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography

P. Mukherjee, A. Miyazawa, L. T. W. Shen, S. Fukuda, T. Yamashita, Y. Oka, I. G. Abd El-Sadek, S. Makita, S. Matsusaka, T. Oshika, H. Kano, Y. Yasuno

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 116301Q (2021) https://doi.org/10.1117/12.2577994
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

A three-dimensional multi-contrast tissue dynamics imaging method based on polarization-sensitive optical coherence tomography is presented to visualize microvascular tissue activity of mouse livers. Temporal variance of birefringence, temporal polarization uniformity and logarithmic OCT intensity variance are used to access the tissue dynamics. These methods are applied to time-course microvasculature activity visualization of dissected normal and inflammatory mouse liver. Multi-contrast projection images are generated to visualize vascular network of the liver. Cross-sectional and en face dynamics images show high activity around the periportal region of mouse liver at initial time point. Degradation of tissue activity is demonstrated by time-lapse imaging.

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P. Mukherjee, A. Miyazawa, L. T. W. Shen, S. Fukuda, T. Yamashita, Y. Oka, I. G. Abd El-Sadek, S. Makita, S. Matsusaka, T. Oshika, H. Kano, and Y. Yasuno "Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 116301Q (9 March 2021); https://doi.org/10.1117/12.2577994

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