Intraoperative margin assessment in head and neck cancer using label-free fluorescence lifetime imaging, machine learning and visualization

Mark Marsden; Brent W. Weyers; Takanori Fukazawa; Tianchen Sun; Julien Bec; Regina F. Gandour-Edwards; Dorina Gui; Andrew C. Birkeland; Arnaud F. Bewley; Marianne Abouyared; D. Gregory Farwell; Laura Marcu

doi:10.1117/12.2577051

5 March 2021 Intraoperative margin assessment in head and neck cancer using label-free fluorescence lifetime imaging, machine learning and visualization

Mark Marsden, Brent W. Weyers, Takanori Fukazawa, Tianchen Sun, Julien Bec, Regina F. Gandour-Edwards, Dorina Gui, Andrew C. Birkeland, Arnaud F. Bewley, Marianne Abouyared, D. Gregory Farwell, Laura Marcu

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Proceedings Volume 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX; 116310N (2021) https://doi.org/10.1117/12.2577051
Event: SPIE BiOS, 2021, Online Only

Abstract

Accurate cancer margin assessment prior to surgical resection is a key factor influencing the long-term survival of oral and oropharyngeal cancer patients. This leads to the need for additional guidance tools for real-time delineation of cancer margins. In this work, fiber-based fluorescence lifetime Imaging (FLIm) was combined with machine learning to perform intraoperative tumor identification. The developed classifier achieved a measurement-level ROC-AUC of 0.89±0.03 on an N=62 patient dataset. A transparent overlay of classifier output was augmented onto the surgical field and updated through tissue motion correction, ensuring co-registration between tissue and spectroscopic data/classifier output was maintained during imaging..

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Mark Marsden, Brent W. Weyers, Takanori Fukazawa, Tianchen Sun, Julien Bec, Regina F. Gandour-Edwards, Dorina Gui, Andrew C. Birkeland, Arnaud F. Bewley, Marianne Abouyared, D. Gregory Farwell, and Laura Marcu "Intraoperative margin assessment in head and neck cancer using label-free fluorescence lifetime imaging, machine learning and visualization", Proc. SPIE 11631, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XIX, 116310N (5 March 2021); https://doi.org/10.1117/12.2577051

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