Three-dimensional imaging of bladder cancer using optical coherence tomography and fluorescence laminar optical tomography

Feng Yan; Venkateshwar Madka; Chen Wang; Trisha I. Valerio; Maegan M. Watson; Jayla A. Wilson; Chinthalapally V. Rao; Qinggong Tang

doi:10.1117/12.2577852

5 March 2021 Three-dimensional imaging of bladder cancer using optical coherence tomography and fluorescence laminar optical tomography

Feng Yan, Venkateshwar Madka, Chen Wang, Trisha I. Valerio, Maegan M. Watson, Jayla A. Wilson, Chinthalapally V. Rao, Qinggong Tang

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Proceedings Volume 11634, Multimodal Biomedical Imaging XVI; 116340M (2021) https://doi.org/10.1117/12.2577852
Event: SPIE BiOS, 2021, Online Only

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Abstract

Early assessment of sub-surface bladder tumor extension is challenging as there are no acceptable imaging modalities to determine sub-surface three-dimensional (3D) tumor extension. Current existing cystoscopy guided transurethral resection technique is limited on direct visualization of tumor surface. In this paper, a multi-modal optical imaging modality combing high-resolution optical coherence tomography (OCT) and depth-resolved high-sensitivity fluorescence laminar optical tomography (FLOT) for structural and molecular imaging was developed. Bladder tissues from UPII-SV40T mice model were imaged by the multi-modal system ex vivo and sub-surface tumor extension was reconstructed. Algorithm was developed to further quantified 3D bladder tumor morphology and molecular alterations.

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Feng Yan, Venkateshwar Madka, Chen Wang, Trisha I. Valerio, Maegan M. Watson, Jayla A. Wilson, Chinthalapally V. Rao, and Qinggong Tang "Three-dimensional imaging of bladder cancer using optical coherence tomography and fluorescence laminar optical tomography", Proc. SPIE 11634, Multimodal Biomedical Imaging XVI, 116340M (5 March 2021); https://doi.org/10.1117/12.2577852

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