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5 March 2021 Dual-contrast high resolution imaging of breast cancer
Androniki Mitrou, Xin Feng, Ashraf Khan, Anna Yaroslavsky
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Proceedings Volume 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis; 1163604 (2021) https://doi.org/10.1117/12.2577323
Event: SPIE BiOS, 2021, Online Only
Abstract
This study investigated the combination of two contrast agents for ex vivo cancer detection in breast tissues. Samples were stained with molecular marker pH Low Insertion Peptide (pHLIP) conjugated with fluorescent dye Alexa532 (pHLIP–Alexa532), and intravital stain Methylene Blue (MB), and imaged with a high-resolution confocal microscope. Resulting images display cellular morphology with staining patterns mimicking Hematoxylin and Eosin histopathology and show promise for the method used as a tool for breast cancer detection in biopsies or intraoperatively.
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Androniki Mitrou, Xin Feng, Ashraf Khan, and Anna Yaroslavsky "Dual-contrast high resolution imaging of breast cancer", Proc. SPIE 11636, Optical Biopsy XIX: Toward Real-Time Spectroscopic Imaging and Diagnosis, 1163604 (5 March 2021); https://doi.org/10.1117/12.2577323
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KEYWORDS
Breast cancer
Breast
Image resolution
Mammography
Tissues
Biopsy
Cancer
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