Edge artifact removal in diffuse optical tomography using the heterogeneous VICTRE digital breast model

Shuying Li; Menghao Zhang; K. M. Shihab Uddin; Quing Zhu

doi:10.1117/12.2576797

5 March 2021 Edge artifact removal in diffuse optical tomography using the heterogeneous VICTRE digital breast model

Shuying Li, Menghao Zhang, K. M. Shihab Uddin, Quing Zhu

Proceedings Volume 11639, Optical Tomography and Spectroscopy of Tissue XIV; 1163905 (2021) https://doi.org/10.1117/12.2576797
Event: SPIE BiOS, 2021, Online Only

Abstract

Ultrasound (US)-guided diffuse optical tomography (DOT) has demonstrated potential value for screening and treatment monitoring of breast cancers. However, in clinical cases, the chest wall, bad probe-tissue contact, and tissue heterogeneity can create image artifacts, causing misinterpretation of lesion images. In the current work, realistic and flexible threedimensional numerical breast phantoms were generated using the Virtual Imaging Clinical Trials for Regulatory Evaluation (VICTRE) tools developed by U.S. Food and Drug Administration (FDA). By selecting physical attributes and tissue optical properties, the VICTRE breast phantoms were, for the first time, adopted in DOT for in silico studies. Monte Carlo simulations were conducted to generate the forward data. Edge artifacts (hot spots on the edge of the regions of interests) were found on the reconstructed images when there was a mismatch between the lesion-side breast and the contralateral reference-side breast. We propose a fully automated, connected components analysis-based algorithm that can remove these edge artifacts and improve lesion reconstruction.

Conference Presentation

Citation Download Citation

Shuying Li, Menghao Zhang, K. M. Shihab Uddin, and Quing Zhu "Edge artifact removal in diffuse optical tomography using the heterogeneous VICTRE digital breast model", Proc. SPIE 11639, Optical Tomography and Spectroscopy of Tissue XIV, 1163905 (5 March 2021); https://doi.org/10.1117/12.2576797

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