A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Raksha Raghunathan; Chih-Hao Liu; Manmohan Singh; Rajesh C. Miranda; Kirill V. Larin

doi:10.1117/12.2583340

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5 March 2021 A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography

Raksha Raghunathan, Chih-Hao Liu, Manmohan Singh, Rajesh C. Miranda, Kirill V. Larin

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Proceedings Volume 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII; 1164109 (2021) https://doi.org/10.1117/12.2583340
Event: SPIE BiOS, 2021, Online Only

Abstract

Prenatal alcohol exposure (PAE) causes a spectrum of abnormalities, collectively termed as fetal alcohol spectrum disorders (FASD). The severity of the defect depends on the amount of alcohol consumed and the period of gestation during which alcohol was consumed. PAE during the second trimester is known to affect fetal brain development as this period of gestation marks the peak period for fetal neurogenesis and angiogenesis. Our previous study evaluated acute changes in fetal brain vasculature after PAE. However, not much has been done to assess concurrent changes on both the fetal and maternal side. This study uses correlation mapping optical coherence angiography (cm-OCA) to evaluate changes in vasculature in the fetal brain and the maternal hindlimb after maternal exposure to alcohol. Results showed drastic vasoconstriction in the fetal brain while vasodilation was seen in the mother, unlike results from the sham group, where there was no significant change in both the fetus and the mother. Changes seen in the fetal brain was similar to our previously published results.

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Raksha Raghunathan, Chih-Hao Liu, Manmohan Singh, Rajesh C. Miranda, and Kirill V. Larin "A comparison of microvasculature changes in the fetal brain and maternal extremities due to prenatal alcohol exposure using optical coherence angiography", Proc. SPIE 11641, Dynamics and Fluctuations in Biomedical Photonics XVIII, 1164109 (5 March 2021); https://doi.org/10.1117/12.2583340

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