Clinical photoacoustic computed tomography of breast cancer treated with neoadjuvant chemotherapy

Li Lin; Xin Tong; Peng Hu; Marta Invernizzi; Lily Lai; Lihong Wang

doi:10.1117/12.2582606

5 March 2021 Clinical photoacoustic computed tomography of breast cancer treated with neoadjuvant chemotherapy

Li Lin, Xin Tong, Peng Hu, Marta Invernizzi, Lily Lai, Lihong Wang

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116420O (2021) https://doi.org/10.1117/12.2582606
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

At present, there is no reliable non-invasive imaging modality accepted as the routine method to assess response to neoadjuvant chemotherapy (NAC). Using photoacoustic computed tomography (PACT), we imaged breast cancer patients at three time points: before, during, and after NAC. We measured the tumor size, blood vascular density, and irregularity in the distribution and morphology of the blood vessels on PACT. We used these measurements to accurately identify response to NAC as confirmed by the histopathological diagnosis. We demonstrate PACT’s near-term potential as a diagnostic tool for assessing breast cancer response to systemic treatment by non-invasively measuring the changes in cancer-associated angiogenesis.

Conference Presentation

Citation Download Citation

Li Lin, Xin Tong, Peng Hu, Marta Invernizzi, Lily Lai, and Lihong Wang "Clinical photoacoustic computed tomography of breast cancer treated with neoadjuvant chemotherapy", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116420O (5 March 2021); https://doi.org/10.1117/12.2582606

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