Assessment of murine heart function post myocardial infraction with volumetric optoacoustic tomography

Ivana Ivankovic; Xosé Luís Deán-Ben; Helena Hass; Melanie A. Kimm; Moritz Wildgruber; Daniel Razansky

doi:10.1117/12.2579234

18 March 2021 Assessment of murine heart function post myocardial infraction with volumetric optoacoustic tomography

Ivana Ivankovic, Xosé Luís Deán-Ben, Helena Hass, Melanie A. Kimm, Moritz Wildgruber, Daniel Razansky

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422H (2021) https://doi.org/10.1117/12.2579234
Event: SPIE BiOS, 2021, Online Only

Abstract

The heart undergoes complex remodeling processes post myocardial infarction (MI), which are yet to be fully understood. Advanced preclinical in vivo imaging tools are key to a better understanding of the processes underlying ischemic damage and cardiac remodeling. Herein, volumetric optoacoustic tomography (VOT) was used to study remodeling patterns at different stages post MI by measuring the pulmonary transit time, ICG perfusion and cardiac cycle irregularities. The real-time, non-invasive, volumetric capabilities of VOT detected differences in remodeling patterns across different MI models, highlighting the feasibility of VOT as a preclinical cardiac imaging tool to study complex murine heart dynamics.

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Citation Download Citation

Ivana Ivankovic, Xosé Luís Deán-Ben, Helena Hass, Melanie A. Kimm, Moritz Wildgruber, and Daniel Razansky "Assessment of murine heart function post myocardial infraction with volumetric optoacoustic tomography", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422H (18 March 2021); https://doi.org/10.1117/12.2579234

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