Dual mode 3D optoacoustic imaging and ultrasound localization microscopy of the mouse brain with spherical matrix array

Justine Robin; Ali Ozbek; Xose-Luis Dean-Ben; Daniel Razanksy

doi:10.1117/12.2578175

5 March 2021 Dual mode 3D optoacoustic imaging and ultrasound localization microscopy of the mouse brain with spherical matrix array

Justine Robin, Ali Ozbek, Xose-Luis Dean-Ben, Daniel Razanksy

Author Affiliations +

Proceedings Volume 11642, Photons Plus Ultrasound: Imaging and Sensing 2021; 116422O (2021) https://doi.org/10.1117/12.2578175
Event: SPIE BiOS, 2021, Online Only

Abstract

Understanding brain function mechanisms relies on tools capable of simultaneous structural and functional imaging at the whole brain scale, with high spatio-temporal resolution, often not attainable in a single imaging modality. Here, we employ spherical matrix array geometry to combine optoacoustic tomography (OAT) and ultrasound localisation microscopy (ULM), and obtain dual-mode volumetric images of the whole mouse brain. Together, OAT allows functional readouts of hemodynamics and oxygen metabolism, while ULM provides structural images of the brain vasculature with a resolution of 20 μm, and flow velocity information up to 10 mm/sec, for a comprehensive characterization of microvascular architecture and function.

Conference Presentation

Citation Download Citation

Justine Robin, Ali Ozbek, Xose-Luis Dean-Ben, and Daniel Razanksy "Dual mode 3D optoacoustic imaging and ultrasound localization microscopy of the mouse brain with spherical matrix array", Proc. SPIE 11642, Photons Plus Ultrasound: Imaging and Sensing 2021, 116422O (5 March 2021); https://doi.org/10.1117/12.2578175

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