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5 March 2021 Epigenetic and cytoskeletal regulation of nuclear mechanics studied with noncontact Brillouin microscopy
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Abstract
The nucleus is the largest and probably stiffest organelle of eukaryotic cells. As such, its mechanical properties are tightly related to various cell functions. However, the mechanical behavior of the nucleus within intact cells is much less know because it is embedded in the cytoplasm thus not directly accessible by the existing contact-based technique. In this work, the regulation of nuclear mechanics was investigated by all-optical Brillouin microscopy and the results were found to be consistent with three-dimensional chemomechanical modeling. We found the intact nuclear mechanics is regulated by both the cytoskeletal networks and internal nanostructure.
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Jitao Zhang, Milos Nikolic, and Giuliano Scarcelli "Epigenetic and cytoskeletal regulation of nuclear mechanics studied with noncontact Brillouin microscopy", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 1164504 (5 March 2021); https://doi.org/10.1117/12.2576981
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