Age-related changes in collagen mechanical properties detected by high-resolution acoustic microscopy and AFM

Anna R. Maeva; Adam P. Strange; Inna Seviaryna; Colin Hopper; Conal Perrett; Hugh Trahair; Oliver Devine; Arne Akbar

doi:10.1117/12.2585637

5 March 2021 Age-related changes in collagen mechanical properties detected by high-resolution acoustic microscopy and AFM

Anna R. Maeva, Adam P. Strange, Inna Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, Arne Akbar

Author Affiliations +

Proceedings Volume 11645, Optical Elastography and Tissue Biomechanics VIII; 116450V (2021) https://doi.org/10.1117/12.2585637
Event: SPIE BiOS, 2021, Online Only

Abstract

Skin aging is a complex process accompanied by alterations in skin structure and function. We have investigated the age-related changes in collagen on dermal collagen’s physical properties. Nanomechanical properties of collagen fibrils studied using atomic force microscope nano-indentation and viscoelasticity of the collagen fibers assessed by the acoustic microscopy was investigated. The increase in Young’s modulus with increased age correlated with the increase in sound speed and attenuation is probably due to a change in the density of the fibrils caused by water retention within the fibrils and cross-linkage between fibrils.

Conference Presentation

Citation Download Citation

Anna R. Maeva, Adam P. Strange, Inna Seviaryna, Colin Hopper, Conal Perrett, Hugh Trahair, Oliver Devine, and Arne Akbar "Age-related changes in collagen mechanical properties detected by high-resolution acoustic microscopy and AFM", Proc. SPIE 11645, Optical Elastography and Tissue Biomechanics VIII, 116450V (5 March 2021); https://doi.org/10.1117/12.2585637

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available