Portable thermo-photonic device for highly sensitive detection and quantification of target analytes in lateral flow immunoassay

Damber Thapa; Nakisa Samadi; Nima Tabatabaei

doi:10.1117/12.2580660

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5 March 2021 Portable thermo-photonic device for highly sensitive detection and quantification of target analytes in lateral flow immunoassay

Damber Thapa, Nakisa Samadi, Nima Tabatabaei

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Proceedings Volume 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics; 1165107 (2021) https://doi.org/10.1117/12.2580660
Event: SPIE BiOS, 2021, Online Only

Abstract

Lateral flow immunoassays (LFAs) are widely used platforms for point-of-care detection of target analytes; however, these rapid tests are not very sensitive and offer only binary results. In this study, highly sensitive thermo-photonic LFA readers were developed for the sensitive detection and quantification of tetrahydrocannabinol (THC) in oral fluids and the antibodies (IgM and IgG) developed against SARS-CoV-2 virus in human blood/plasma. Our results suggest developed readers not only improved the detection limit by more than an order of magnitude, but also enables reliable quantification of target analytes.

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Damber Thapa, Nakisa Samadi, and Nima Tabatabaei "Portable thermo-photonic device for highly sensitive detection and quantification of target analytes in lateral flow immunoassay", Proc. SPIE 11651, Optical Diagnostics and Sensing XXI: Toward Point-of-Care Diagnostics, 1165107 (5 March 2021); https://doi.org/10.1117/12.2580660

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