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5 March 2021 Real-time monitoring of blood clots in extracorporeal life support by intelligent platelet aggregate characterizer
Yuqi Zhou, Atsushi Yasumoto, Masako Nishikawa, Yuya Nobori, Ting-Hui Xiao, Yutaka Yatomi, Masaki Anraku, Keisuke Goda
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Proceedings Volume 11654, High-Speed Biomedical Imaging and Spectroscopy VI; 116540S (2021) https://doi.org/10.1117/12.2577425
Event: SPIE BiOS, 2021, Online Only
Abstract
In COVID-19 therapy with artificial lungs such as extracorporeal membrane oxygenation (ECMO) machines, platelets in the extracorporeal circulation are often activated by their contact with the artificial materials, leading to the formation of blood clots followed by serious complications such as stroke and heart attack. However, anticoagulation and antithrombotic management is challenging due to the lack of testing tools to evaluate the circulation. Here we demonstrate real-time monitoring of thrombogenesis in the circulation of an ECMO-equipped goat with an intelligent platelet aggregate characterizer (iPAC), which is based on imaging flow cytometry and deep-learning-based analysis of numerous platelet aggregates in blood.
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Yuqi Zhou, Atsushi Yasumoto, Masako Nishikawa, Yuya Nobori, Ting-Hui Xiao, Yutaka Yatomi, Masaki Anraku, and Keisuke Goda "Real-time monitoring of blood clots in extracorporeal life support by intelligent platelet aggregate characterizer", Proc. SPIE 11654, High-Speed Biomedical Imaging and Spectroscopy VI, 116540S (5 March 2021); https://doi.org/10.1117/12.2577425
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KEYWORDS
Blood
Animal model studies
Diagnostics and therapeutics
Flow cytometry
Image analysis
Ischemia
Lung
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