Three-dimensional imaging of mouse liver dynamics by polarization-sensitive optical coherence tomography

Pradipta Mukherjee; Arata Miyazawa; Shinichi Fukuda; Toshiharu Yamashita; Ibrahim Abd El-Sadek; Shuichi Makita; Tetsuro Oshika; Yoshiaki Yasuno

doi:10.1117/12.2577974

5 March 2021 Three-dimensional imaging of mouse liver dynamics by polarization-sensitive optical coherence tomography

Pradipta Mukherjee, Arata Miyazawa, Shinichi Fukuda, Toshiharu Yamashita, Ibrahim Abd El-Sadek, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno

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Proceedings Volume 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021; 116550O (2021) https://doi.org/10.1117/12.2577974
Event: SPIE BiOS, 2021, Online Only

Abstract

In this paper, we demonstrate polarization-sensitive optical coherence tomography (PS-OCT) based tissue dynamics imaging methods to investigate the activity of mouse livers. The methods include logarithmic intensity variance (LIV), temporal variance of birefringence, temporal degree-of-polarization-uniformity. Portal veins appeared as hypo-scattering structure in static OCT intensity. High dynamics appearance around the portal veins in all the dynamics contrasts was found just after the dissection of mouse liver. Although, high activity around the vessels reduced by time, a bright and high dynamics spot appeared in the vessel in LIV cross-sectional and en face image after 28-hours of the dissection.

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Pradipta Mukherjee, Arata Miyazawa, Shinichi Fukuda, Toshiharu Yamashita, Ibrahim Abd El-Sadek, Shuichi Makita, Tetsuro Oshika, and Yoshiaki Yasuno "Three-dimensional imaging of mouse liver dynamics by polarization-sensitive optical coherence tomography", Proc. SPIE 11655, Label-free Biomedical Imaging and Sensing (LBIS) 2021, 116550O (5 March 2021); https://doi.org/10.1117/12.2577974

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