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5 March 2021 Near infrared photoimmunotherapy for cancer; New targets on cancer and immune-suppressive cells
Hisataka Kobayashi
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Proceedings Volume 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII; 1166003 (2021) https://doi.org/10.1117/12.2577639
Event: SPIE BiOS, 2021, Online Only
Abstract
Near infrared photoimmunotherapy (NIR-PIT) is a new type of molecularly-targeted cancer photo-therapy, which employs a NIR silica-phthalocyanine, IR700, conjugated to a monoclonal antibody targeting cell-surface molecules. NIR-PIT targeting EGFR is now in transition to fast-track Phase 3 trial in late-stage recurrent head and neck squamous cell cancer patients. I will focus on successful cancer-targeting and immune-suppressive cell-targeting NIR-PIT against new targets; podoplanin, PD-L1, and CTLA-4 that could treat broad spectra of cancers. Furthermore, the regimens of cancer-targeting NIR-PIT combined with immune-suppressive cell-targeting NIR-PIT could cure primary and metastatic tumor and yield vaccination effect against treated cancer cells.
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Hisataka Kobayashi "Near infrared photoimmunotherapy for cancer; New targets on cancer and immune-suppressive cells", Proc. SPIE 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, 1166003 (5 March 2021); https://doi.org/10.1117/12.2577639
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KEYWORDS
Cancer
Near infrared
Photoimmunotherapy
Cell death
Tumors
Head
Molecules
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