Dual fluorescence guidance improves extent of brain tumor removal surgery

Haini Zhang; Suman Mondal; Dorota Grabowska; Matt Mixdorf; Gail P. Sudlow; Christine M. O'Brien; Julie Prior; Kexian Liang; Rui Tang; Samuel Achilefu

doi:10.1117/12.2577287

5 March 2021 Dual fluorescence guidance improves extent of brain tumor removal surgery

Haini Zhang, Suman Mondal, Dorota Grabowska, Matt Mixdorf, Gail P. Sudlow, Christine M. O'Brien, Julie Prior, Kexian Liang, Rui Tang, Samuel Achilefu

Author Affiliations +

Proceedings Volume 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII; 1166009 (2021) https://doi.org/10.1117/12.2577287
Event: SPIE BiOS, 2021, Online Only

Abstract

LS301 is a promising NIR fluorescence probe for targeting brain glioma cancer. The co-localization of LS31 and 5-ALA induced PpIX in vitro and in vivo enables LS301 to guide PpIX fluorescence image surgery. Moreover, LS301 showed no negative impact on 5-ALA-PpIX PDT outcome in brain glioma cells and mouse tumor model. Therefore, the implementation of LS301 and PpIX has potential to improve tumor resection surgery and PDT treatment for better tumor outcomes.

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Haini Zhang, Suman Mondal, Dorota Grabowska, Matt Mixdorf, Gail P. Sudlow, Christine M. O'Brien, Julie Prior, Kexian Liang, Rui Tang, and Samuel Achilefu "Dual fluorescence guidance improves extent of brain tumor removal surgery", Proc. SPIE 11660, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XIII, 1166009 (5 March 2021); https://doi.org/10.1117/12.2577287

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