Absolute quantum advantage in microscopy

Warwick P. Bowen; Catxere A. Casacio; Lars S. Madsen; Alex Terrasson; Muhammad Waleed; Kai Barnscheidt; Boris Hage; Michael A. Taylor

doi:10.1117/12.2587141

5 March 2021 Absolute quantum advantage in microscopy

Warwick P. Bowen, Catxere A. Casacio, Lars S. Madsen, Alex Terrasson, Muhammad Waleed, Kai Barnscheidt, Boris Hage, Michael A. Taylor

Author Affiliations +

Proceedings Volume 11700, Optical and Quantum Sensing and Precision Metrology; 117002A (2021) https://doi.org/10.1117/12.2587141
Event: SPIE OPTO, 2021, Online Only

Abstract

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this absolute quantum advantage, achieving signal-to-noise beyond the photodamage-free capacity of conventional microscopy. We achieve this in a coherent Raman microscope, which we use to image molecular bonds within a cell with both quantum-enhanced contrast and sub-wavelength resolution. This allows the observation of nanoscale biological structures that would otherwise not be resolved. Coherent Raman microscopes allow highly selective biomolecular finger-printing in unlabelled specimens, but photodamage is a major roadblock for many applications. By showing that this roadblock can be overcome, our work provides a path towards order-of-magnitude improvements in both sensitivity and imaging speed.

Conference Presentation

Citation Download Citation

Warwick P. Bowen, Catxere A. Casacio, Lars S. Madsen, Alex Terrasson, Muhammad Waleed, Kai Barnscheidt, Boris Hage, and Michael A. Taylor "Absolute quantum advantage in microscopy", Proc. SPIE 11700, Optical and Quantum Sensing and Precision Metrology, 117002A (5 March 2021); https://doi.org/10.1117/12.2587141

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