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13 February 1990 A Fiberoptic Antibody-Based Biosensor With Time-Resolved Detection
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Abstract
A phase-resolved fiberoptic antibody-based biosensor is desci ibed, which combines the biochemical specificity of antigen-antibody reaction, the high sensitivity of laser excitation, the versatility of fiberoptic sensors, and the selectivity of phase-resolved detection. The device can differentiate benzo(a)pyrene and benzo(a)pyrene tetrol, a DNA-adduct product of the carcinogen benzo(a)pyrene. The limit of detection of benzo(a)pyrene tetrol is in the attomole range (10-18 moles).
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
T. Vo-Dinh, T. Nolan, Y. F. Cheng, J. P. Alarie, and M. J. Sepaniak "A Fiberoptic Antibody-Based Biosensor With Time-Resolved Detection", Proc. SPIE 1172, Chemical, Biochemical, and Environmental Fiber Sensors, (13 February 1990); https://doi.org/10.1117/12.963196
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