IN2SIGHT: an in vivo bioengineered chip for new validation protocols of biomaterials

Giuseppe Chirico

doi:10.1117/12.2595057

24 June 2021 IN2SIGHT: an in vivo bioengineered chip for new validation protocols of biomaterials

Giuseppe Chirico

Proceedings Volume 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V; 1178608 (2021) https://doi.org/10.1117/12.2595057
Event: SPIE Optical Metrology, 2021, Online Only

Abstract

I will review the fundamental limiting issues in in-vivo optical imaging and discuss the proposal made by the IN2SIGHT consortium to overcome them and its impact. IN2SIGHT will foster a breakthrough in in-vivo optical imaging that will renovate the biocompatibility tests (ISO10993 EU norm) required for the development of biomaterials for clinical use. These tests are economical and ethical unsustainable for small-medium industries and for the society. The IN2SIGHT approach stands on a micro-structured chip that will recast our thinking of deep tissue in-vivo imaging. I discuss how this proposal will allow unique quantification of the immune reaction to biomaterials, thus reducing time and costs for testing with a potential huge impact on public health systems and our society. The project sees the collaboration of seven partners from five countries and will exploit from the beginning inter-sectorial approaches in an interdisciplinary environment.

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Citation Download Citation

Giuseppe Chirico "IN2SIGHT: an in vivo bioengineered chip for new validation protocols of biomaterials", Proc. SPIE 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V, 1178608 (24 June 2021); https://doi.org/10.1117/12.2595057

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KEYWORDS

In vivo imaging

Optical imaging

Deep tissue imaging

Laser tissue interaction

Polymerization

Two photon polymerization

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