Unidirectional optical mechano-sensing with upconversion nanoparticles

Kory Green; Brandon Long; Kai Huang; Gang Han; Hans Hallen; Shuang Fang Lim

doi:10.1117/12.2597041

1 August 2021 Unidirectional optical mechano-sensing with upconversion nanoparticles

Kory Green, Brandon Long, Kai Huang, Gang Han, Hans Hallen, Shuang Fang Lim

Proceedings Volume 11825, Ultrafast Nonlinear Imaging and Spectroscopy IX; 118250V (2021) https://doi.org/10.1117/12.2597041
Event: SPIE Optical Engineering + Applications, 2021, San Diego, California, United States

Abstract

Cells respond to forces, and their quantification can potentially inform on the role of mechanics in cell development, differentiation, tissue repair and homeostasis. Other force sensitive processes include cancer cell metastasis, heart development in embryos driven by fluid forces, and individual cell response to tension by enhancing microtubule growth and connections. Development of current mechano-sensing approaches has not yielded many options, especially in directional force measurement. We present a sharpened fiber-based approach for uniaxial forces. An upconversion nanoparticle (UCNP) is mounted on the tip of the fiber and optically accessed through the fiber, which is manipulated as a probe. In UCNPs, the modification of the crystal field via mechanical forces result in changes in emission intensity, spectral shifts, upconversion luminescence (UCL) lifetime and ratiometric UCL response. We report on a discernably large peak shift of between 5-10 nm, and an apparent phase transition, with increasing amount of applied force in the micro Newton regime, in a single direction. Moreover, the peak shift is linear to the applied compression force. We investigate the influence of the UCNP force sensing process using Raman spectroscopy.

Conference Presentation

Citation Download Citation

Kory Green, Brandon Long, Kai Huang, Gang Han, Hans Hallen, and Shuang Fang Lim "Unidirectional optical mechano-sensing with upconversion nanoparticles", Proc. SPIE 11825, Ultrafast Nonlinear Imaging and Spectroscopy IX, 118250V (1 August 2021); https://doi.org/10.1117/12.2597041

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