X-ray phase-contrast computed tomography for full breast mastectomy imaging at the Australian Synchrotron

Benedicta D. Arhatari; Yakov I. Nesterets; Seyedamir T. Taba; Anton Maksimenko; Christopher J. Hall; Andrew W. Stevenson; Daniel Häsermann; Sarah J. Lewis; Matthew Dimmock; Darren Thompson; Sheridan C. Mayo; Harry M. Quiney; Timur E. Gureyev; Patrick C. Brennan

doi:10.1117/12.2596225

9 September 2021 X-ray phase-contrast computed tomography for full breast mastectomy imaging at the Australian Synchrotron

Benedicta D. Arhatari, Yakov I. Nesterets, Seyedamir T. Taba, Anton Maksimenko, Christopher J. Hall, Andrew W. Stevenson, Daniel Häsermann, Sarah J. Lewis, Matthew Dimmock, Darren Thompson, Sheridan C. Mayo, Harry M. Quiney, Timur E. Gureyev, Patrick C. Brennan

Author Affiliations +

Proceedings Volume 11840, Developments in X-Ray Tomography XIII; 1184012 (2021) https://doi.org/10.1117/12.2596225
Event: SPIE Optical Engineering + Applications, 2021, San Diego, California, United States

Abstract

One of the imaging modalities offered by the Imaging and Medical Beamline (IMBL) at the Australian Synchrotron is Xray phase-contrast propagation-based computed tomography (PB-CT). The unique combination of high coherence and high brightness of radiation produced by synchrotron X-ray sources enables phase contrast imaging with excellent sensitivity to small density differences in soft tissues and tumors. The PB-CT images using spatially coherent radiation show high signal-to-noise ratio (SNR) without reducing the spatial resolution. This is due to the combined effect of forward free-space propagation and the advanced step of phase retrieval in the reconstruction processes that allows to accommodate noisier recorded images. This gives an advantage of potentially reducing the radiation dose delivered to the sample whilst preserving the reconstructed image quality. It is expected that the PB-CT technique will be well suited for diagnostic breast imaging in the near future with the advantage that it could provide better tumor detection and characterization/grading than mammography and other breast imaging modalities/techniques in general. The PB-CT technique is expected to reduce false negative and false positive cancer diagnoses that result from overlapping regions of tissue in 2D mammography and avoid patient pain and discomfort that results from breast compression. The present paper demonstrates that PB-CT produces superior results for imaging low-density materials such as breast mastectomy samples, when compared to the conventional absorption-based CT collected at the same radiation dose. The performance was quantified in terms of both the measured objective image characteristics and the subjective scores from radiological assessments. This work is part of the ongoing research project aimed at the introduction of 3D X-ray medical imaging at the IMBL as innovative tomographic methods to improve the detection and diagnosis of breast cancer. Major progress of this project includes the characterization of a large number of mastectomy samples, both normal and cancerous.

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Benedicta D. Arhatari, Yakov I. Nesterets, Seyedamir T. Taba, Anton Maksimenko, Christopher J. Hall, Andrew W. Stevenson, Daniel Häsermann, Sarah J. Lewis, Matthew Dimmock, Darren Thompson, Sheridan C. Mayo, Harry M. Quiney, Timur E. Gureyev, and Patrick C. Brennan "X-ray phase-contrast computed tomography for full breast mastectomy imaging at the Australian Synchrotron", Proc. SPIE 11840, Developments in X-Ray Tomography XIII, 1184012 (9 September 2021); https://doi.org/10.1117/12.2596225

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