Ultrasonic modes to improve the optical clearing of the skin ex vivo

Daria K. Tuchina; Alexey N. Bashkatov; Nikita A. Navolokin; Valery V. Tuchin

doi:10.1117/12.2589230

4 May 2021 Ultrasonic modes to improve the optical clearing of the skin ex vivo

Daria K. Tuchina, Alexey N. Bashkatov, Nikita A. Navolokin, Valery V. Tuchin

Proceedings Volume 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine; 1184507 (2021) https://doi.org/10.1117/12.2589230
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

The experimental study of ultrasonic modes was performed for ex vivo skin samples of white Wistar rats. The ultrasound was provided by a Dynatron 125 US system (Dynatronics, USA) after applying an optical clearing agent aqueousalcohol- fructose (20%-30%-50%) solution to the sample surface. Three different ultrasonic modes were used to found the most effective and fastest optical clearing. The optical coherence tomography system, Spectral Radar OCT System OCP930SR 022 (Thorlabs Inc., USA) with a wavelength of 930 nm, was used for obtaining the quantitative data for effectiveness and rate of skin optical clearing. The best mode had a frequency of 3 MHz and a power of 1.5 W in continuous wave mode for 3 minutes.

Citation Download Citation

Daria K. Tuchina, Alexey N. Bashkatov, Nikita A. Navolokin, and Valery V. Tuchin "Ultrasonic modes to improve the optical clearing of the skin ex vivo", Proc. SPIE 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine, 1184507 (4 May 2021); https://doi.org/10.1117/12.2589230

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