Improved optical access of laser radiation to the brain using optical clearing and transparent cranial implants: review

Alaa Shanshool; Valery V. Tuchin

doi:10.1117/12.2593090

4 May 2021 Improved optical access of laser radiation to the brain using optical clearing and transparent cranial implants: review

Alaa Shanshool, Valery V. Tuchin

Author Affiliations +

Proceedings Volume 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine; 118450W (2021) https://doi.org/10.1117/12.2593090
Event: Saratov Fall Meeting 2020, 2020, Saratov, Russian Federation

Abstract

The light source-based medical techniques for brain imaging, diagnosis, and treatment are very common clinical tools. However, applying these techniques is limited due to the high attenuation of light in the scalp and skull. Such optical attenuation reduces the achievable spatial resolution and precludes the visualization of small features such as brain microvessels. The present study aims to clarify the current methods for providing a desired optical access to the brain with good visualization of the microvessels. The strategy involves the use of transparent cranial implants and optical clearing agents to improve the optical access for laser speckle imaging of cerebral microvasculature. In vivo laser speckle imaging experiments of the mouse, cerebral blood vessels showed that the proposed optical access with combined transmittance of the optically cleared scalp overlying the transparent cranial implant increased signal to noise ratio and image resolution, allowing for visualization of microvessels through the transparent implant, which was not possible through the uncleared scalp and intact skull.

Citation Download Citation

Alaa Shanshool and Valery V. Tuchin "Improved optical access of laser radiation to the brain using optical clearing and transparent cranial implants: review", Proc. SPIE 11845, Saratov Fall Meeting 2020: Optical and Nanotechnologies for Biology and Medicine, 118450W (4 May 2021); https://doi.org/10.1117/12.2593090

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