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The core mismatch formed by the splicing of different fiber cores and tapered fiber is beneficial to the sensing. In this paper, a single-mode fiber (SMF)- tapered multi-mode fiber (tapered MMF)-single-mode fiber structure was fabricated and used as a sensor to detect uric acid. The gold nanoparticles (AuNPs)/zinc oxide (ZnO) nanoparticles were fixed on the tapered surface to enhance the localized surface plasmon resonance (LSPR) and its sensing performance. The experimental results show that the optical fiber sensor can detect different concentrations of uric acid solution successfully and has a linear response in a certain range for biomedical applications.
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