In vivo monitoring the disfunction of blood brain barrier and microglia in diabetic mice

Shaojun Liu; Dongyu Li; Tingting Yu; Dan Zhu

doi:10.1117/12.2600780

9 October 2021 In vivo monitoring the disfunction of blood brain barrier and microglia in diabetic mice

Shaojun Liu, Dongyu Li, Tingting Yu, Dan Zhu

Author Affiliations +

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119001S (2021) https://doi.org/10.1117/12.2600780
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

Diabetes can not only disrupt the blood brain barrier and the homeostasis of brain microenvironment, but also affect the function of immune cells. Since diabetes is a chronic disease, it is of great value to investigate the changes of various physiological indicators with the development of diabetes, while there are few relevant studies. In this work, the changes of blood brain barrier and microglial function in mice with the development of diabetes was in vivo monitored, using recently arisen skull optical clearing window with a variety of optical imaging techniques. The results showed that with the development of diabetes mellitus, the permeability of the blood brain barrier in the cortex of mice increased gradually, which further induced the morphological and functional changes of microglia. This study is expected to provide a reference for the study of diabetic complications, as well as interventional treatment and efficacy evaluation of diabetes mellitus.

Citation Download Citation

Shaojun Liu, Dongyu Li, Tingting Yu, and Dan Zhu "In vivo monitoring the disfunction of blood brain barrier and microglia in diabetic mice", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119001S (9 October 2021); https://doi.org/10.1117/12.2600780

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