Using multiphoton microscopy to image the skin of mouse psoriasis model

Zhen Li; Yulan Liu; Yu Yi; Xiahui Han; Lianhuang Li; Shulian Wu; Jianxin Chen; Yelin Wu; Liqin Zheng

doi:10.1117/12.2602440

9 October 2021 Using multiphoton microscopy to image the skin of mouse psoriasis model

Zhen Li, Yulan Liu, Yu Yi, Xiahui Han, Lianhuang Li, Shulian Wu, Jianxin Chen, Yelin Wu, Liqin Zheng

Proceedings Volume 11900, Optics in Health Care and Biomedical Optics XI; 119002Z (2021) https://doi.org/10.1117/12.2602440
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Conference Poster

Abstract

Psoriasis is a common chronic inflammatory skin disease with high prevalence, chronicity, disfiguration, disability. Real-time detection of psoriatic pathological characteristics by optical technology is of great significance for the diagnosis and treatment of psoriasis. We used multiphoton microscopy (MPM) imaging technology based on intrinsic nonlinear optical signals to image the skin of a mouse psoriasis model induced by imiquimod (IMQ). The changes of cells and collagen in psoriasis skin tissue were obtained and analyzed, comparing with the hematoxylin and eosin (H and E) stained image. We found that the MPM technique could clearly observe the differences between normal and psoriasis skin. This is of great significance to the pathogenesis of psoriasis and also provides adjuvant imaging method for the treatment of psoriasis.

Citation Download Citation

Zhen Li, Yulan Liu, Yu Yi, Xiahui Han, Lianhuang Li, Shulian Wu, Jianxin Chen, Yelin Wu, and Liqin Zheng "Using multiphoton microscopy to image the skin of mouse psoriasis model", Proc. SPIE 11900, Optics in Health Care and Biomedical Optics XI, 119002Z (9 October 2021); https://doi.org/10.1117/12.2602440

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