In this paper, localized surface plasmon resonance (LSPR) based tapered multimode optical fiber (TMMF) sensor is developed for the detection of different concentrations of p-cresol solutions. Gold nanoparticles (AuNPs) and molybdenum disulfide nanoparticles (MoS2-NPs) were immobilized on TMMF probes, respectively. The performance of the designed probe was explored by detecting the response of different concentrations of p-cresol solutions. The combination of AuNPs and MoS2-NPs enhances the sensitivity and anti-interference ability of the sensing probe. In this work, the enzymatic reaction of p-cresol solution and tyrosinase changes the RI in the vicinity of the probe and records the corresponding spectrum. The probe will also be evaluated in terms of linear range, limit of detection (LoD), reproducibility, reproducibility, stability, selectivity, etc.
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