Graphene based terahertz sensing scheme for cancer biomarker measurement in liquid environment

Jialiang Huang; Xudong Liu; Yiwen Sun

doi:10.1117/12.2602657

9 October 2021 Graphene based terahertz sensing scheme for cancer biomarker measurement in liquid environment

Jialiang Huang, Xudong Liu, Yiwen Sun

Proceedings Volume 11906, Infrared, Millimeter-Wave, and Terahertz Technologies VIII; 119060I (2021) https://doi.org/10.1117/12.2602657
Event: SPIE/COS Photonics Asia, 2021, Nantong, JS, China

Abstract

Terahertz spectroscopy, with the advantages of label-free and non-ionizing has been considered as a potential method for biomolecule detection. Hereby we present a promising approach for the label-free protein sensing in liquid environment. In this work, we designed a grapheme-based device to increase the accumulated amount of protein molecules in the solution. The sensor demonstrates a quick and sensitive response to HER2 proteins and gave a linearly response to the concentrations of HER2 from 63 ng/ml to 4.0 μg/mL. The results demonstrated that once HER2 molecules targeting on the surface of graphene, the conductivity of graphene was significantly changed. This provided us a potential method to detect trace biomarker within liquid phase by using terahertz spectroscopy.

Citation Download Citation

Jialiang Huang, Xudong Liu, and Yiwen Sun "Graphene based terahertz sensing scheme for cancer biomarker measurement in liquid environment", Proc. SPIE 11906, Infrared, Millimeter-Wave, and Terahertz Technologies VIII, 119060I (9 October 2021); https://doi.org/10.1117/12.2602657

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