Quantitative measurement of low-concentration analytes using Raman spectroscopy during droplet evaporation for therapeutic drug monitoring

Sora Tomita; Terumasa Ito; Kazuyuki Iwaikawa; Gen Hayase; Daisuke Yoshino; Kazuhiko Misawa

doi:10.1117/12.2614937

7 December 2021 Quantitative measurement of low-concentration analytes using Raman spectroscopy during droplet evaporation for therapeutic drug monitoring

Sora Tomita, Terumasa Ito, Kazuyuki Iwaikawa, Gen Hayase, Daisuke Yoshino, Kazuhiko Misawa

Author Affiliations +

Proceedings Volume 11919, Translational Biophotonics: Diagnostics and Therapeutics; 119191Q (2021) https://doi.org/10.1117/12.2614937
Event: European Conferences on Biomedical Optics, 2021, Online Only

Abstract

We propose a new method for therapeutic drug monitoring using Raman spectroscopy to quantify the concentration of analytes during droplet evaporation. The proposed method is demonstrated for quantitative measurement of methotrexate down to 0.5 mM

Citation Download Citation

Sora Tomita, Terumasa Ito, Kazuyuki Iwaikawa, Gen Hayase, Daisuke Yoshino, and Kazuhiko Misawa "Quantitative measurement of low-concentration analytes using Raman spectroscopy during droplet evaporation for therapeutic drug monitoring", Proc. SPIE 11919, Translational Biophotonics: Diagnostics and Therapeutics, 119191Q (7 December 2021); https://doi.org/10.1117/12.2614937

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