Automated Detection Of Chromosome Aberration Using Color Information

Chung-Ho Chen; Yao Wang; Sanjit K. Mitra; Joe W. Gray

doi:10.1117/12.969746

1 March 1990 Automated Detection Of Chromosome Aberration Using Color Information

Chung-Ho Chen; Yao Wang; Sanjit K. Mitra; Joe W. Gray;

Author Affiliations +

Proceedings Volume 1192, Intelligent Robots and Computer Vision VIII: Algorithms and Techniques; (1990) https://doi.org/10.1117/12.969746
Event: 1989 Symposium on Visual Communications, Image Processing, and Intelligent Robotics Systems, 1989, Philadelphia, PA, United States

Abstract

An automated scheme for the detection of chromosome aberrations in color chromosome images is described. The analysis scheme consists of three steps: segmentation, clustering, and scene understanding. First the target chromosome pixels are segmented via thresholding based on a chosen color measure. Then a clustering technique is applied to cluster the target chromosome pixels into groups in such a way that every group corresponds to a unique target chromosome domain. Finally, human chromosome aberrations are detected by calculating the geometrical properties of each detected group and counting the number of the confirmed target chromosomes. Experiments have been carried out to compare the effectiveness of several color measures for the purpose of the segmentation. Moreover, a novel self-tuning thresholding method has been developed to improve the robustness of segmentation. With this method, chromosome aberrations can be idetified even under different background brightness and chrominance distribution.

Citation Download Citation

Chung-Ho Chen, Yao Wang, Sanjit K. Mitra, Joe W. Gray, "Automated Detection Of Chromosome Aberration Using Color Information", Proc. SPIE 1192, Intelligent Robots and Computer Vision VIII: Algorithms and Techniques, (1 March 1990); doi: 10.1117/12.969746; https://doi.org/10.1117/12.969746

ACCESS THE FULL ARTICLE

PERSONAL SIGN IN
Full access may be available with your subscription

Email or Username Forgot your username?

Password Forgot your password?

Show

Remember Email/Username on this computer

Remember Password

No SPIE account? Create an account
or Institutional Sign In via Shibboleth

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members: $14.40

Non-members: $18.00 ADD TO CART

Show All Keywords

Keywords/Phrases

Search In:

Publication Years