Towards infrared photonic integrated circuits (PICs) in biochemical analysis: implementation of quantum cascade lasers (QCLs) in analysis of fluids

T. B. Daunis; J. C. Dussor; B. Le; K. P. Hodges; K. P. Clark; D. I. Robbins; K. Roodenko

doi:10.1117/12.2615367

2 March 2022 Towards infrared photonic integrated circuits (PICs) in biochemical analysis: implementation of quantum cascade lasers (QCLs) in analysis of fluids

T. B. Daunis, J. C. Dussor, B. Le, K. P. Hodges, K. P. Clark, D. I. Robbins, K. Roodenko

Author Affiliations +

Proceedings Volume 11953, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXII; 119530A (2022) https://doi.org/10.1117/12.2615367
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

There is a growing demand for hand-held and/or field-grade sensors for biochemical analysis of fluids. These systems have applications in monitoring of nitrogen-based compounds (such as nitrate and ammonia) in the wastewater treatment industry; bacterial detection in drinking water; analysis of biofluids, such as urine or blood; and in many other areas. Mid-infrared (midIR) spectroscopy is a powerful tool for identification and quantification of a wide range of common organic and inorganic compounds. Although IR radiation is strongly absorbed in water, this technology can be adapted for analysis of fluids by utilizing the principles of attenuated total reflection (ATR). In this contribution we highlight the application of IR spectroscopy in wastewater analysis as well as for metabolomic analysis in bioreactors. We discuss the requirements for IR signal stability that are necessary for biochemical analysis of fluids and provide examples of challenges encountered during transition from FTIR to a QCL-based platform. Overall, our stepwise efforts target eventual integration of a QCL light source, waveguide sensor, and IR detector onto a single photonic integrated circuit (PIC) for applications in the defense sector as well as for a broad consumer market.

Citation Download Citation

T. B. Daunis, J. C. Dussor, B. Le, K. P. Hodges, K. P. Clark, D. I. Robbins, and K. Roodenko "Towards infrared photonic integrated circuits (PICs) in biochemical analysis: implementation of quantum cascade lasers (QCLs) in analysis of fluids", Proc. SPIE 11953, Optical Fibers and Sensors for Medical Diagnostics, Treatment and Environmental Applications XXII, 119530A (2 March 2022); https://doi.org/10.1117/12.2615367

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available