Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy

Pradipta Mukherjee; Shinchi Fukuda; Donny Lukmanto; Toshiharu Yamashita; Kosuke Okada; Shuichi Makita; Ibrahim Abd El-Sadek; Arata Miyazawa; Lida Zhu; Tetsuro Oshika; Yoshiaki Yasuno

doi:10.1117/12.2608443

2 March 2022 Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy

Pradipta Mukherjee, Shinchi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Tetsuro Oshika, Yoshiaki Yasuno

Author Affiliations +

Proceedings Volume 11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022; 1197208 (2022) https://doi.org/10.1117/12.2608443
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

We demonstrate label-free imaging of renal function with a unilateral ureteral obstruction (UUO) kidney mouse model. The imaging was performed by optical coherence microscopy which is capable of measuring tissue dynamics. Two different studies comprising of 1-week and 2-week UUO models were performed. A circular ring-shape high dynamics appearance at the periphery of the tissue surface was found in the 1-week UUO model for both obstructed and contralateral non-obstructed kidneys. In the 2-week UUO model, several vertical high dynamics regions were observed in cross-sectional dynamics images for both obstructed and non-obstructed kidneys. The results were validated by histological analysis.

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Pradipta Mukherjee, Shinchi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Tetsuro Oshika, and Yoshiaki Yasuno "Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy", Proc. SPIE 11972, Label-free Biomedical Imaging and Sensing (LBIS) 2022, 1197208 (2 March 2022); https://doi.org/10.1117/12.2608443

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