Superferromagnetic iron oxide: a new paradigm for color multiplex and FRET-like nanoscale 'ruler' for magnetic particle imaging

Zhi Wei Tay; Shehaab Savliwala; Daniel Hensley; Prashant Chandrasekharan; Barry Fung; Caylin Colson; Benjamin Fellows; Sindia Rivera-Jimenez; Malini Olivo; Carlos Rinaldi; Steven M. Conolly

doi:10.1117/12.2607431

3 March 2022 Superferromagnetic iron oxide: a new paradigm for color multiplex and FRET-like nanoscale 'ruler' for magnetic particle imaging

Zhi Wei Tay, Shehaab Savliwala, Daniel Hensley, Prashant Chandrasekharan, Barry Fung, Caylin Colson, Benjamin Fellows, Sindia Rivera-Jimenez, Malini Olivo, Carlos Rinaldi, Steven M. Conolly

Author Affiliations +

Proceedings Volume 11977, Colloidal Nanoparticles for Biomedical Applications XVII; 1197704 (2022) https://doi.org/10.1117/12.2607431
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Superferromagnetic iron oxide (SFMIOs) is a new paradigm for Magnetic Particle Imaging (MPI) as it approaches the ideal imaging agent characteristics of a steep, step-like magnetization curve. Other than the expected 10-fold SNR and spatial resolution improvements from the square-like hysteresis curve, we demonstrate other unique qualities of SFMIOs that enable robust "chemical-shift-like" color multiplexing to potentially enable a range of magnetic "dyes" that work for at-depth imaging. We also demonstrate the extremely high sensitivity of SFMIO signal to the proximity of SFMIOs to each other, and explain how this could potentially be used as a FRET-like nanoscale ruler.

Conference Presentation

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Zhi Wei Tay, Shehaab Savliwala, Daniel Hensley, Prashant Chandrasekharan, Barry Fung, Caylin Colson, Benjamin Fellows, Sindia Rivera-Jimenez, Malini Olivo, Carlos Rinaldi, and Steven M. Conolly "Superferromagnetic iron oxide: a new paradigm for color multiplex and FRET-like nanoscale 'ruler' for magnetic particle imaging", Proc. SPIE 11977, Colloidal Nanoparticles for Biomedical Applications XVII, 1197704 (3 March 2022); https://doi.org/10.1117/12.2607431

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