Hematocrit independent in-vivo measurement of oxygen saturation and indocyanine green concentration with a CCD array camera

Thomas Schroeder; Rainer Pahl M.D.; Jens Peter Hering; Gerhard Hellige M.D.

doi:10.1117/12.17555

1 July 1990 Hematocrit independent in-vivo measurement of oxygen saturation and indocyanine green concentration with a CCD array camera

Thomas Schroeder, Rainer Pahl M.D., Jens Peter Hering, Gerhard Hellige M.D.

Author Affiliations +

Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17555
Event: OE/LASE '90, 1990, Los Angeles, CA, United States

Abstract

A method was developed to measure 02-saturation and Indocyanine-green concentration without external haematocrit correction by recording reflection spectra with a fiberoptic catheter and a CCD array camera, connected with ap-computer. The calculation is based on evaluation of the whole spectrum. Thereby it was shown that it is possible to determine Indocyanine-green and O2-satrati0n and to correct the haematocrit using three wavelengths instead of two wavelengths as usually done. The calculation differs from conventional methods not only in the additional wavelength, but also in the bandwidths used. When compared with extracorporal photometric transmission reference techniques the correlation coefficients of O2-saturation are r=O.996 (n=67) in vitro and r=O.993 (n=267) in vivo, and the coefficients of Indocyanine-green are r=O.996 (n=87) in vitro and r=O.998 (n=107) in vivo. In comparison with the same reference technique, a conventional commercial fiberoptic reflection photometer (IVH3, Fa. Schwarzer, MUnchen, Germany) using LED's at two wavelengths and requiring haematocrit correction showed somewhat poorer linearity and correlation coefficients. [ Indocyanine-green, in vivo r=O.995 (n=96); 02-saturation, in vivo r=O.976 (n=92) I

Citation Download Citation

Thomas Schroeder, Rainer Pahl M.D., Jens Peter Hering, and Gerhard Hellige M.D. "Hematocrit independent in-vivo measurement of oxygen saturation and indocyanine green concentration with a CCD array camera", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); https://doi.org/10.1117/12.17555

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