1 July 1990 Surface-enhanced Raman spectroscopy of peptides
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Proceedings Volume 1201, Optical Fibers in Medicine V; (1990) https://doi.org/10.1117/12.17604
Event: OE/LASE '90, 1990, Los Angeles, CA, United States
Surface-enhanced Raman (SER) spectroscopy has been used to probe the adsorption, surface interactions, and orientations of peptides on metal surfaces. Amino acids in homodipeptides give SER spectra with unique features that can be used to characterize the surface interactions of specific functional groups in more complicated peptides. In heterodipeptides, there is a hierarchy of functional group-surface interactions that prescribe their orientation and conformation on metal surfaces. By establishing this hierarchy, it is now possible to predict the interactions that occur between larger peptides and surfaces. Furthermore, the observed trends suggest that it should be possible to control these interactions by varying the solution pH, the charge on the surface, and other parameters of the measurement in order to adsorb species selectively from mixtures of peptides in solution. Potential biomedical applications of this technique will be described.
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Robin L. Garrell, Robin L. Garrell, Tonya M. Herne, Tonya M. Herne, Angela M. Ahern, Angela M. Ahern, Eve L. Sullenberger, Eve L. Sullenberger, } "Surface-enhanced Raman spectroscopy of peptides", Proc. SPIE 1201, Optical Fibers in Medicine V, (1 July 1990); doi: 10.1117/12.17604; https://doi.org/10.1117/12.17604

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