1 June 1990 Monitoring the efficiency of photodynamic therapy in tissue
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Proceedings Volume 1202, Laser-Tissue Interaction; (1990) https://doi.org/10.1117/12.17614
Event: OE/LASE '90, 1990, Los Angeles, CA, United States
Abstract
Transcutaneous oxygen electrodes are used to non-invasively measure tissue oxygen tension during photodynamic therapy (PDT). Measurements are performed on VX-2 skin carcinomas in rabbit ears. The degree of tumor oxygen tension reduction is proportional to the applied light dose. In the absence of irradiation, oxygen tension returns to pre-irradiation levels until a "damage threshold" has been reached. For 50mW/cm2 irradiations of Photofrmn II (at 630 nm) and tetraphenylporphine tetrasulfonate (at 657 tim), the cumulative dose required to irreversibly deplete tumor iranscutaneous oxygen was approximately 300 kJ/M2 and 600 kJ/M2, respectively.
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Arie Orenstein, Arie Orenstein, Sol Kimel, Sol Kimel, Bruce J. Tromberg, Bruce J. Tromberg, J. Stuart Nelson, J. Stuart Nelson, Michael W. Berns, Michael W. Berns, } "Monitoring the efficiency of photodynamic therapy in tissue", Proc. SPIE 1202, Laser-Tissue Interaction, (1 June 1990); doi: 10.1117/12.17614; https://doi.org/10.1117/12.17614
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