1 July 1990 Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors
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Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17667
Event: OE/LASE '90, 1990, Los Angeles, CA, United States
Abstract
The photodynarnic effects of bacteriochlorophyll-a (bchl-a) , a sensitizer of high light absorption at long wavelengths, are greatly influenced by its rapid degradation in vivo to also photodynamically active pheophytins and chlorophylls. This can result in overall tumor destruction and direct tumor cell kill over a wide range of different wavelengths, although tumor curability is restricted to the bchl-a wavelength of 780 nm. Tumor cures are also limited to treatment conditions where light follows drug injection after a brief interval (2 hours) . The major mechanism of tumor destruction appears to be vascular. Normal tissue photosensitivity induced by 780 nm light declines rapidly with time after sensitizer injection.
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Barbara W. Henderson, Barbara W. Henderson, William R. Potter, William R. Potter, Adam B. Sumlin, Adam B. Sumlin, Barbara Owczarczak, Barbara Owczarczak, F. S. Nowakowski, F. S. Nowakowski, Thomas J. Dougherty, Thomas J. Dougherty, } "Bacteriochlorophyll-a as photosensitizer for photodynamic treatment of transplantable murine tumors", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17667; https://doi.org/10.1117/12.17667
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