1 July 1990 Diagnosis of tumors by fluorescence: quantification of photosensitizer concentration
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Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17646
Event: OE/LASE '90, 1990, Los Angeles, CA, United States
Abstract
The concentration of Photofrmn II is needed to determine the dose in photodynamic therapy, and in fluorescence diagnosis of tumors. A method based on fluorescence was devised which shows promise. Diffusion theory was applied in slab geometry with closely spaced excitation and emission wavelengths. A function of the measured radiant energy fluences for excitation and emission, and the depth x, was found that canceled the dependence on depth. A function of the diffusion coefficient and attenuation coefficient was derived from the measured diffuse reflectance. This function compensated for differences in absorption and scattering in different tissues, or a calibration phantom and tissue. Comparisons should be made with the concentration derived in other ways, but the fluorescence method shows promise.
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
A. Edward Profio, A. Edward Profio, Shusen Xie, Shusen Xie, Kuang-Hsien Shu, Kuang-Hsien Shu, } "Diagnosis of tumors by fluorescence: quantification of photosensitizer concentration", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17646; https://doi.org/10.1117/12.17646
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