1 July 1990 Immunological effects of photodynamic therapy
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Proceedings Volume 1203, Photodynamic Therapy: Mechanisms II; (1990) https://doi.org/10.1117/12.17659
Event: OE/LASE '90, 1990, Los Angeles, CA, United States
Abstract
There are few reports in the literature regarding the effect that photodynamic therapy (PDT) might have on immune function. illumination of skin with light in the long UV range is well known to have immunosuppressive properties mediated by the amplification of a subpopulation of T suppressor cells1. However, PDT effected by light at between 600 and 700 nm and accompanied by an acute inflammatory response has not been studied in depth in terms of its influence on immune function. A few recent reports have documented suppression of immune function in the days immediately following PDTZ3. In one report, the cells responsible for this suppressive effect were characterized as a non-T cell population which were incapable of adoptively transferring the effect2. It is probable that the cells responsible for transient immunosupppression following PDT are activated macrophages, no doubt stimulated by the photodynamic effect and well known for their release ofprostaglandin E2 which is non-specifically immunosuppressive. On the other hand, there is anecdotal evidence from clinical studies attesting to what might be interpreted as immunological enhancement following PDT (infiltration of lymphocytes into inflammatory lesions), as well as reports of elevated levels of interleukin 2 (IL-2) in the urine of patients treated with PDT for bladder cancer'5. Some investigators have reported lymphokine involvement in photodynamically initiated lesions6. Recent work by Gomer and his associates have shown positive correlation with PDT and enhanced natural killer cell activity7 and have suggested that this could play a role in reduction of the metastatic potential of surviving tumor cells8.
© (1990) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Patricia M. Logan, Patricia M. Logan, Jo-anne Newton, Jo-anne Newton, Anna M. Richter, Anna M. Richter, Stephen Yip, Stephen Yip, Julia G. Levy, Julia G. Levy, "Immunological effects of photodynamic therapy", Proc. SPIE 1203, Photodynamic Therapy: Mechanisms II, (1 July 1990); doi: 10.1117/12.17659; https://doi.org/10.1117/12.17659
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