A cascaded deep network for automated tumor detection and segmentation in clinical PET imaging of diffuse large B-cell lymphoma

Shadab Ahamed; Natalia Dubljevic; Ingrid Bloise; Claire Gowdy; Patrick Martineau; Don Wilson; Carlos F. Uribe; Arman Rahmim; Fereshteh Yousefirizi

doi:10.1117/12.2612684

4 April 2022 A cascaded deep network for automated tumor detection and segmentation in clinical PET imaging of diffuse large B-cell lymphoma

Shadab Ahamed, Natalia Dubljevic, Ingrid Bloise, Claire Gowdy, Patrick Martineau, Don Wilson, Carlos F. Uribe, Arman Rahmim, Fereshteh Yousefirizi

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Proceedings Volume 12032, Medical Imaging 2022: Image Processing; 120323M (2022) https://doi.org/10.1117/12.2612684
Event: SPIE Medical Imaging, 2022, San Diego, California, United States

Conference Poster

Abstract

Accurate detection and segmentation of diffuse large B-cell lymphoma (DLBCL) from PET images has important implications for estimation of total metabolic tumor volume, radiomics analysis, surgical intervention and radiotherapy. Manual segmentation of tumors in whole-body PET images is time-consuming, labor-intensive and operator-dependent. In this work, we develop and validate a fast and efficient three-step cascaded deep learning model for automated detection and segmentation of DLBCL tumors from PET images. As compared to a single end-to-end network for segmentation of tumors in whole-body PET images, our three-step model is more effective (improves 3D Dice score from 58.9% to 78.1%) since each of its specialized modules, namely the slice classifier, the tumor detector and the tumor segmentor, can be trained independently to a high degree of skill to carry out a specific task, rather than a single network with suboptimal performance on overall segmentation.

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Shadab Ahamed, Natalia Dubljevic, Ingrid Bloise, Claire Gowdy, Patrick Martineau, Don Wilson, Carlos F. Uribe, Arman Rahmim, and Fereshteh Yousefirizi "A cascaded deep network for automated tumor detection and segmentation in clinical PET imaging of diffuse large B-cell lymphoma", Proc. SPIE 12032, Medical Imaging 2022: Image Processing, 120323M (4 April 2022); https://doi.org/10.1117/12.2612684

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